RNA Details
Disease Name
pulmonary arterial hypertension
Tissue
lung
RNA Symbol
PTPN11
RNA ID
RNA Type
mRNA
Alteration Pattern
down regulation
Species
homo sapiens
Detection Methods
TLDAS; qRT-PCR; Dual-luciferase reporter assay etc.
Target
SHP2
Pathway
STAT3-MIR-204-SRC-STAT3-NFAT signaling pathway
PubMed ID
Title
Role for miR-204 in human pulmonary arterial hypertension
Year
2011
Function
"MiR-204 expression in PASMCs is down-regulated in both human and rodent PAH. MiR-204 down-regulation correlates with PAH severity and accounts for the proliferative and antiapoptotic phenotypes of PAH-PASMCs. STAT3 activation suppresses miR-204 expression, and miR-204 directly targets SHP2 expression, thereby SHP2 up-regulation, by miR-204 down-regulation, activates the Src kinase and nuclear factor of activated T cells (NFAT). STAT3 also directly induces NFATc2 expression. NFAT and SHP2 were needed to sustain PAH-PASMC proliferation and resistance to apoptosis. Finally, delivery of synthetic miR-204 to the lungs of animals with PAH significantly reduced disease severity."